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Ere transfected with non-targeted (NT) or PKC siRNA after which treated with 3 g/ml U18666A or car for 24 hrs. XTT assay was performed to measure cell viability. Data are imply SD, p0.01. (B) PKC expression was determined by quantitative real-time PCR. Data are mean SD, p0.001. (C, D) 6-week-old Npc1 flox/-, Pcp2-Cre mice had been injected with AAV2 expressing HSPB1-3E or handle vector and after t

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