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Cellular GSSG levels increased drastically in manage cells treated with H2O2. In MRP1 silenced cells, the basal amount of GSSG was higher than manage cells and when incubated with H2O2, a six.eight fold enhance in GSSG levels was observed over scrambled controls. GSH efflux decreased by a substantial 60% in MRP1 silenced cells with no further modify with H2O2 therapy. The corresponding efflux for
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